Date Published:

Abstract:

Myelin is synthesized as a multilamellar membrane, but the mechanisms of membrane turnover are unknown. We found that myelin pieces were gradually released from aging myelin sheaths and were subsequently cleared by microglia. Myelin fragmentation increased with age and led to the formation of insoluble, lipofuscin-like lysosomal inclusions in microglia. Thus, age-related myelin fragmentation is substantial, leading to lysosomal storage and contributing to microglial senescence and immune dysfunction in aging.

Notes:

Safaiyan, ShimaKannaiyan, NirmalSnaidero, NicolasBrioschi, SimoneBiber, KnutYona, SimonEdinger, Aimee LJung, SteffenRossner, Moritz JSimons, MikaelengResearch Support, Non-U.S. Gov'tNat Neurosci. 2016 Aug;19(8):995-8. doi: 10.1038/nn.4325. Epub 2016 Jun 13.