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The annexin-1 knockout mouse: what it tells us about the inflammatory response | Mononuclear Phagocyte Immunobiology Group
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The annexin-1 knockout mouse: what it tells us about the inflammatory response

Citation:

Roviezzo, F. et al., 2002. The annexin-1 knockout mouse: what it tells us about the inflammatory response. J Physiol Pharmacol, 53, pp.541-53.

Date Published:

Dec

Abstract:

The 37kDa protein annexin 1 (Anx-1; lipocortin 1) is a glucocorticoid-regulated protein that has been implicated in the regulation of phagocytosis, cell signalling and proliferation, and postulated to be a mediator of glucocorticoids action in inflammation and in the control of anterior pituitary hormone release. Immuno-neutralisation or antisense strategies support this hypothesis as they can reverse the effect of glucocorticoids in several systems. We recently generated a line of mice lacking the Anx-1 gene noting that some tissues taken from such animals exhibited an increased expression of several proteins including COX-2 and cPLA2. In models of experimental inflammation, Anx-1(-/-) mice exhibit an exaggerated response and a partial or complete resistance to the anti-inflammatory effects of glucocorticoids. Several other anomalies were noted including abnormal leukocyte adhesion molecule expression, an increased spontaneous migratory behaviour of PMN in Anx-1(-/-) mice and a resistance in Anx-1(-/-) macrophages to glucocorticoid inhibition of superoxide generation. This paper reviews these and other data in the light of the development of the 'second messenger' hypothesis of glucocorticoid action.

Notes:

Roviezzo, FGetting, S JPaul-Clark, M JYona, SGavins, F N EPerretti, MHannon, RCroxtall, J DBuckingham, J CFlower, R JengResearch Support, Non-U.S. Gov'tReviewPolandJ Physiol Pharmacol. 2002 Dec;53(4 Pt 1):541-53.