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Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation | Mononuclear Phagocyte Immunobiology Group
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Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation

Citation:

Wolf, Y. et al., 2017. Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation. J Exp Med, 214, pp.905-917.

Date Published:

Apr 3

Abstract:

Monocytes are circulating mononuclear phagocytes, poised to extravasate to sites of inflammation and differentiate into monocyte-derived macrophages and dendritic cells. Tumor necrosis factor (TNF) and its receptors are up-regulated during monopoiesis and expressed by circulating monocytes, as well as effector monocytes infiltrating certain sites of inflammation, such as the spinal cord, during experimental autoimmune encephalomyelitis (EAE). In this study, using competitive in vitro and in vivo assays, we show that monocytes deficient for TNF or TNF receptors are outcompeted by their wild-type counterpart. Moreover, monocyte-autonomous TNF is critical for the function of these cells, as TNF ablation in monocytes/macrophages, but not in microglia, delayed the onset of EAE in challenged animals and was associated with reduced acute spinal cord infiltration of Ly6C(hi) effector monocytes. Collectively, our data reveal a previously unappreciated critical cell-autonomous role of TNF on monocytes for their survival, maintenance, and function.

Notes:

Wolf, YochaiShemer, AnatPolonsky, MichalGross, MorMildner, AlexanderYona, SimonDavid, EyalKim, Ki-WookGoldmann, TobiasAmit, IdoHeikenwalder, MathiasNedospasov, SergeiPrinz, MarcoFriedman, NirJung, Steffeneng340345/European Research Council/InternationalResearch Support, Non-U.S. Gov'tJ Exp Med. 2017 Apr 3;214(4):905-917. doi: 10.1084/jem.20160499. Epub 2017 Mar 22.