Citation:
Gilroy, D.W. & Yona, S., 2015. HIF1alpha allows monocytes to take a breather during sepsis. Immunity, 42, pp.397-9.
Date Published:
Mar 17Abstract:
How the immune system is negatively affected by sepsis is not fully understood. In this issue of Immunity, Shalova et al. (2015) show that during human sepsis monocytes upregulate hypoxia-inducible factor-alpha (HIF1-alpha) activity and acquire an immunosuppressive phenotype while retaining anti-bacterial and wound-healing properties.
Notes:
Gilroy, Derek WYona, Simoneng087520/Wellcome Trust/United KingdomCommentImmunity. 2015 Mar 17;42(3):397-9. doi: 10.1016/j.immuni.2015.02.016.