Date Published:

Abstract:

Historical data suggested that a soluble protein, since identified as annexin-A1 (Anx-A1) was released from macrophages following glucocorticoid stimulation and could modulate eicosanoid production and other functions of these cells. Here, we review some recent findings using a line of Anx-A1(-/-) mice to explore the impact of Anx-A1 gene deletion on macrophage biology. The absence of Anx-A1 selectively alters phagocytic capacity of rodent resident peritoneal macrophages apparently through changes in surface adhesion molecule expression. Anx-A1 is also apparently important in the tonic down-regulation of other macrophage functions such as COX-2 induction, PGE(2) release and the production of reactive oxygen species.

Notes:

Yona, SWard, BarbaraBuckingham, Julia CPerretti, MFlower, R JengResearch Support, Non-U.S. Gov'tReviewScotlandProstaglandins Leukot Essent Fatty Acids. 2005 Feb;72(2):95-103. doi: 10.1016/j.plefa.2004.10.008.